| Primary Identifier | MGI:2682376 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Pdgfrb |
| Transmission | Germline | Strain of Origin | 129S4/SvJaeSor |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | 5 point mutations were engineered and incorporated at the endogenous locus via homologous recombination of a targeting vector. Each mutation elicited a missense mutation, ablating tyrosine residues involved in PI3-K, RasGAP, SHP-2, and PLC-gamma signal transduction. Tyrosines at codons 739, 750, 770, and 1008 are substituted with phenylalanine, and a tyrosine at 1020 is substituted with isoleucine. A single loxP site was left in intron 16. |
