| First Author | Markovich D | Year | 2011 |
| Journal | Exp Gerontol | Volume | 46 |
| Issue | 10 | Pages | 833-5 |
| PubMed ID | 21651971 | Mgi Jnum | J:186744 |
| Mgi Id | MGI:5432998 | Doi | 10.1016/j.exger.2011.05.008 |
| Citation | Markovich D, et al. (2011) Increased lifespan in hyposulfatemic NaS1 null mice. Exp Gerontol 46(10):833-5 |
| abstractText | Sulfate (SO(4)(2-)) plays an important role in mammalian growth and development. In this study, hyposulfatemic NaS1 null (Nas1-/-) mice were used to investigate the consequences of perturbed SO(4)(2-) homeostasis on longevity. Median life spans were increased (by approximately 25%) in male and female Nas1-/- mice when compared with Nas1+/+ mice. At 1 yr of age, serum SO(4)(2-) levels remained low in Nas1-/- mice ( approximately 0.16 mM) when compared to Nas1+/+ mice ( approximately 0.96 mM). RT-PCR revealed increased hepatic mRNA levels of Sirt1 (by approximately 60%), Cat (by approximately 48%), Hdac3 (by approximately 22%), Trp53 and Cd55 (by approximately 36%) in Nas1-/- mice, genes linked to ageing. Histological analyses of livers from 2 yr old mice revealed neoplasms in >50% of Nas1+/+ mice but not in Nas1-/- mice. This is the first study to report increased lifespan, decreased hepatic tumours and increased hepatic expression of genes linked to ageing in hyposulfatemic Nas1-/- mice, implicating a potential role of SO(4)(2-) in mammalian longevity and cancer. |
