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Allele : Zap70<m1Saka> zeta-chain (TCR) associated protein kinase; mutation 1, Shimon Sakaguchi

Primary Identifier	MGI:2683318	Allele Type	Spontaneous
Gene	Zap70	Inheritance Mode	Recessive
Strain of Origin	BALB/c	Is Recombinase	false
Is Wild Type	false

molecularNote

A G-to-T transversion at coding nucleotide 489 (c.489G>T), resulting in a tryptophan to cysteine substitution at codon 163 (p.W163C), was identified on a BALB/c genetic background.

mutations:
Single point mutation

synonyms:
ZAP-70<W163C>,
ZAP-70<skg>,
SKG,
ZAP-70<skg>,
SKG,
ZAP-70<W163C>

earliestPublication:
Sakaguchi N, et al. (2003) Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 426(6965):454-60

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

23 Publication categories

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