| First Author | Chen AI | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 6 | Pages | 689-98 |
| PubMed ID | 10626891 | Mgi Jnum | J:59203 |
| Mgi Id | MGI:1351152 | Doi | 10.1016/s1074-7613(00)80143-0 |
| Citation | Chen AI, et al. (1999) Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity 11(6):689-98 |
| abstractText | The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a potential costimulatory molecule and also has been implicated in T cell homing and B cell activation. To ascertain the essential functions of Ox40L, we generated and characterized Ox40L-deficient mice. Mice lacking Ox40L exhibit an impaired contact hypersensitivity response, a dendritic cell-dependent T cell-mediated response, due to defects in T cell priming and cytokine production. In contrast, Ox40L-deficient mice do not have defects in T cell homing or humoral immune responses. In vitro, Ox40L-deficient dendritic cells are defective in costimulating T cell cytokine production. Thus, Ox40L has a critical costimulatory function in vitro and in vivo for dendritic cell:T cell interactions. |
