| First Author | Millership S | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 51 | Pages | 20943-8 |
| PubMed ID | 23213245 | Mgi Jnum | J:193097 |
| Mgi Id | MGI:5467653 | Doi | 10.1073/pnas.1210022110 |
| Citation | Millership S, et al. (2012) Increased lipolysis and altered lipid homeostasis protect gamma-synuclein-null mutant mice from diet-induced obesity. Proc Natl Acad Sci U S A 109(51):20943-8 |
| abstractText | Synucleins are a family of homologous proteins principally known for their involvement in neurodegeneration. gamma-Synuclein is highly expressed in human white adipose tissue and increased in obesity. Here we show that gamma-synuclein is nutritionally regulated in white adipose tissue whereas its loss partially protects mice from high-fat diet (HFD)-induced obesity and ameliorates some of the associated metabolic complications. Compared with HFD-fed WT mice, HFD-fed gamma-synuclein-null mutant mice display increased lipolysis, lipid oxidation, and energy expenditure, and reduced adipocyte hypertrophy. Knockdown of gamma-synuclein in adipocytes causes redistribution of the key lipolytic enzyme ATGL to lipid droplets and increases lipolysis. gamma-Synuclein-deficient adipocytes also contain fewer SNARE complexes of a type involved in lipid droplet fusion. We hypothesize that gamma-synuclein may deliver SNAP-23 to the SNARE complexes under lipogenic conditions. Via these independent but complementary roles, gamma-synuclein may coordinately modulate lipid storage by influencing lipolysis and lipid droplet formation. Our data reveal gamma-synuclein as a regulator of lipid handling in adipocytes, the function of which is particularly important in conditions of nutrient excess. |
