| First Author | Willaime-Morawek S | Year | 2006 |
| Journal | J Cell Biol | Volume | 175 |
| Issue | 1 | Pages | 159-68 |
| PubMed ID | 17030986 | Mgi Jnum | J:114513 |
| Mgi Id | MGI:3689256 | Doi | 10.1083/jcb.200604123 |
| Citation | Willaime-Morawek S, et al. (2006) Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells. J Cell Biol 175(1):159-68 |
| abstractText | Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells from midgestation into adulthood. Lineage tracing in combination with direct cell labeling and time-lapse video microscopy demonstrated that Emx1-lineage embryonic cortical stem cells migrate ventrally into the striatal germinal zone (GZ) perinatally and intermingle with striatal stem cells. Upon integration into the striatal GZ, cortical stem cells down-regulate Emx1 and up-regulate Dlx2, which is a homeobox gene characteristic of the developing striatum and striatal neural stem cells. This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain. |
