| First Author | Zhang H | Year | 2019 |
| Journal | Mol Neurobiol | Volume | 56 |
| Issue | 6 | Pages | 4072-4085 |
| PubMed ID | 30264295 | Mgi Jnum | J:314823 |
| Mgi Id | MGI:6823183 | Doi | 10.1007/s12035-018-1358-4 |
| Citation | Zhang H, et al. (2019) Upregulation of MicroRNA miR-9 Is Associated with Microcephaly and Zika Virus Infection in Mice. Mol Neurobiol 56(6):4072-4085 |
| abstractText | Proper growth of the mammalian cerebral cortex, which is determined by expansion and survival of neural progenitors and mature neurons, is crucial for cognitive functions. Here, we show a role of the dosage of microRNA miR-9 in controlling brain size. Cortical-specific upregulation of miR-9 causes microcephalic defects in mice, due to apoptosis, reduced neural progenitor pool, and decreased neurogenesis. Glial cell-derived neurotrophic factor (GDNF) is a target of miR-9, and protects neural progenitors from miR-9-induced apoptosis. Furthermore, Zika virus (ZIKV) infection in embryonic mouse cortex causes reduced numbers in neural progenitors and newborn neurons, and results in upregulation of miR-9, downregulation of its target GDNF. Our studies indicate an association of altered levels of miR-9 and its target GDNF with microcephaly and ZIKV infection in mice. |
