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Allele : Noct<tm1Bjc> nocturnin; targeted mutation 1, J C Besharse

Primary Identifier	MGI:2686733	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Noct
Transmission	Germline	Strain of Origin	129S2/SvPas
Is Recombinase	false	Is Wild Type	false

molecularNote

The entire coding region of exon 3, which contains most of the protein coding sequence including the catalytic domain, was replaced with a neomycin resistance cassette. Absence of protein was confirmed in mutant liver homogenates.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
Noc<->,
Noc<->

earliestPublication:
Green CB, et al. (2007) Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity. Proc Natl Acad Sci U S A 104(23):9888-93

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

11 Publication categories

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