| Primary Identifier | MGI:3026703 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Efnb3 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The loxP-flanked lacZ cassette was removed from Efnb2tm1.1Henk (frt-flanked neo excised from Efnb2tm1Henk) via cre-mediated recombination, generating a stop codon in exon 5. The nonsense mutation precludes the translation of the cytoplasmic tail (beyond codon 264). This allele is expected to encode a protein similar to Efnb2tm1.1Henk, but lacking beta-gal. Similarly, this mutation is expected to ablate reverse signaling while leaving forward signaling intact. |
