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Allele : Icos<tm1Flv> inducible T cell co-stimulator; targeted mutation 1, Richard A Flavell

Primary Identifier	MGI:2683635	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Icos
Transmission	Germline	Strain of Origin	129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

The three exons for all of the amino acid coding sequence except the leader peptide were replaced with a PGK-neomycin resistance cassette. Absence of protein product was demonstrated immunologically.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
ICOS<->,
ICOS<->

earliestPublication:
Dong C, et al. (2001) ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409(6816):97-101

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

3 Carried By

0 Driven By

39 Publication categories

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