| First Author | Tai TS | Year | 2013 |
| Journal | J Immunol | Volume | 190 |
| Issue | 1 | Pages | 428-37 |
| PubMed ID | 23225883 | Mgi Jnum | J:190818 |
| Mgi Id | MGI:5449760 | Doi | 10.4049/jimmunol.1201361 |
| Citation | Tai TS, et al. (2013) GATA-3 Regulates the Homeostasis and Activation of CD8+ T Cells. J Immunol 190(1):428-37 |
| abstractText | GATA-3, a C2C2-type zinc finger transcription factor, regulates many steps of T cell development and differentiation. It is also required for optimal production of type 2 cytokines by CD8(+) T cells. However, its role in the development and function of this subset of T cells is still poorly characterized. In this paper, we report that GATA-3 is required for MHC-mediated positive selection and final maturation of CD8 single-positive thymocytes. Deficiency of GATA-3 mediated by a CD4cre transgene led to age-dependent lymphadenopathy partly because of abnormal expansion of CD8(+) T cells driven by a cell-extrinsic mechanism. Paradoxically, GATA-3-deficient CD8(+) T cells were hyporesponsive to Ag stimulation due to a defect in the maintenance/progression, but not initiation, of activation signals. More importantly, GATA-3-deficient CD8(+) T cells were less efficient in killing Ag-bearing tumor cells in vivo. Taken together, our data further expand the role of GATA-3 in T cells. |
