| First Author | Ruefli-Brasse AA | Year | 2003 |
| Journal | Science | Volume | 302 |
| Issue | 5650 | Pages | 1581-4 |
| PubMed ID | 14576442 | Mgi Jnum | J:86770 |
| Mgi Id | MGI:2682077 | Doi | 10.1126/science.1090769 |
| Citation | Ruefli-Brasse AA, et al. (2003) Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science 302(5650):1581-4 |
| abstractText | Paracaspase (MALT1), a member of an evolutionarily conserved superfamily of caspase-like proteins, has been shown to bind and colocalize with the protein Bcl10 in vitro and, because of this association, has been suggested to be involved in the CARMA1-Bcl10 pathway of antigen-induced nuclear factor kappaB (NF-kappaB) activation. We demonstrate that primary T and B lymphocytes from paracaspase-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation. Paracaspase acts downstream of Bcl10 to induce NF-kappaB activation and is required for the normal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and activation of the IkappaB kinase complex. |
