| First Author | Compan V | Year | 2004 |
| Journal | J Neurosci | Volume | 24 |
| Issue | 2 | Pages | 412-9 |
| PubMed ID | 14724239 | Mgi Jnum | J:87451 |
| Mgi Id | MGI:2687138 | Doi | 10.1523/JNEUROSCI.2806-03.2004 |
| Citation | Compan V, et al. (2004) Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci 24(2):412-9 |
| abstractText | To study the functions of 5-HT4 receptors, a null mutation was engineered in the corresponding gene. 5-HT4 receptor knock-out mice displayed normal feeding and motor behaviors in baseline conditions but abnormal feeding and locomotor behavior in response to stress and novelty. Specifically, stress-induced hypophagia and novelty-induced exploratory activity were attenuated in the knock-out mice. In addition, pentylenetetrazol-induced convulsive responses were enhanced in the knock-out mice, suggesting an increase in neuronal network excitability. These results provide the first example of a genetic deficit that disrupts the ability of stress to reduce feeding and body weight and suggest that 5-HT4 receptors may be involved in stress-induced anorexia and seizure susceptibility. |
