| Primary Identifier | MGI:2684314 | Allele Type | Targeted |
| Attribute String | Conditional ready, Inserted expressed sequence, Reporter | Gene | Gt(ROSA)26Sor |
| Transmission | Germline | Strain of Origin | 129S4/SvJaeSor |
| Is Recombinase | false | Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: Liposarcoma, Dedifferentiated J:237232 in double Gt(ROSA)26Sortm1(Notch1)Dam and Tg(Adipoq-cre)1Evdr mutants. Phenotypic Similarity to Human Syndrome: Osteosclerosis J: 233131 in double Gt(ROSA)26Sortm1(Notch1)Dam and Tg(Col1a1-cre)1Kry mutants. |
| molecularNote | A targeting vector containing a floxed neo cassette followed by a mouse Notch1 sequence fragment and GFP was inserted at the endogenous locus. Excision of the floxed neo cassette leads to the expression of the Notch1 sequence encoding an intracellular portion of NOTCH1 (amino acids 1749-2293), but lacking the c-terminal PEST domain. IRES preceded the sequence encoding the nuclear-localized enhanced GFP. |
