| First Author | Dong H | Year | 2023 |
| Journal | Cancer Lett | Volume | 567 |
| Pages | 216283 | PubMed ID | 37331584 |
| Mgi Jnum | J:337827 | Mgi Id | MGI:7508858 |
| Doi | 10.1016/j.canlet.2023.216283 | Citation | Dong H, et al. (2023) PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET. Cancer Lett 567:216283 |
| abstractText | Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPRO(low)/p-MET(high) had significantly poor prognosis, suggesting that PTPRO(low)/p-MET(high) can serve as an independent prognostic factor for patients with ESCC. |
