| Primary Identifier | MGI:3027060 | Allele Type | Transgenic |
| Attribute String | Recombinase | Gene | Tg(Rr291-cre)6-1Clou |
| Strain of Origin | (C57BL/6J x SJL)F2 | Is Recombinase | true |
| Is Wild Type | false |
| description | Founder lines 6-1 and 6-2 were generated. In general, the expression from line 6-1 was stronger than that of line 6-2 in all areas other than the brain. |
| molecularNote | The intergenic distal-less homeobox 5/6 enhancer (mI56i) is a 440 bp fragment, endogenously located between Dlx5 and Dlx6. In this transgenic construct, mouse mI56i was included immediately downstream of cDNA encoding a nuclear localization signal and cre. Additionally, a minimal beta-globin promoter was included in the construct. Expression of cre recombinase was first realized at E9.5 and observed in the apical ectodermal ridge, brain, and neural crest-derived mesenchyme of pharyngeal. Additional indications of expression were identified along the smooth muscle of the outflow tract of the heart, however, this pattern was not observed in the 6-2 line. |
