| First Author | Corcoran LM | Year | 1994 |
| Journal | Immunity | Volume | 1 |
| Issue | 8 | Pages | 635-45 |
| PubMed ID | 7600291 | Mgi Jnum | J:28350 |
| Mgi Id | MGI:75968 | Doi | 10.1016/1074-7613(94)90035-3 |
| Citation | Corcoran LM, et al. (1994) Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. Immunity 1(8):635-45 |
| abstractText | Oct-2, a POU homeodomain protein expressed primarily in B cells, is a powerful transcriptional activator that binds to DNA at sites appropriately placed for major effects on immunoglobulin gene expression. Our examination of B cell development and function in Oct-2 null mice did not support an essential role for Oct-2 early in B cell development. Rather, Oct-2 was required later, when B cells were induced to differentiate to antibody-secreting cells. We show here that Oct-2 is not required for normal immunoglobulin production by mature B lymphocytes. Instead, it is essential for a normal proliferative response to polyclonal mitogens. Responses to signals from activated T cells are unaffected. The requirement for Oct-2 maps to an early activation step in G1, during which B cells make the commitment to progress through the cell cycle and to divide. |
