| First Author | Bánvölgyi A | Year | 2005 |
| Journal | J Neuroimmunol | Volume | 169 |
| Issue | 1-2 | Pages | 86-96 |
| PubMed ID | 16188326 | Mgi Jnum | J:106387 |
| Mgi Id | MGI:3618432 | Doi | 10.1016/j.jneuroim.2005.08.012 |
| Citation | Banvolgyi A, et al. (2005) Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model. J Neuroimmunol 169(1-2):86-96 |
| abstractText | The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides. |
