Primary Identifier | MGI:3029662 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(MMTV-Catnb)3Pac |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | To express catenin beta in the epithelium of the mammary ducts, cDNA encoding Xenopus catenin beta was adjoined to a mouse mammary tumor virus long terminal repeat. The encoded catenin beta protein lacks 89 amino terminal residues, retains cadherin/catenin binding, and has increased stability in the cytoplasmic pool. Beta globin sequence and a myc epitope tag were also included in the construct. Founder mice contained a single copy of the construct and were considered "low expressing" relative to line 5. |