| First Author | Imbert A | Year | 2001 |
| Journal | J Cell Biol | Volume | 153 |
| Issue | 3 | Pages | 555-68 |
| PubMed ID | 11331306 | Mgi Jnum | J:69210 |
| Mgi Id | MGI:1934298 | Doi | 10.1083/jcb.153.3.555 |
| Citation | Imbert A, et al. (2001) Deltan89beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J Cell Biol 153(3):555-68 |
| abstractText | To investigate the role of beta-catenin in mammary gland development and neoplasia, we expressed a stabilized, transcriptionally active form of beta-catenin lacking the NH(2)-terminal 89 amino acids (DeltaN89beta-catenin) under the control of the mouse mammary tumor virus long terminal repeat. Our results show that DeltaN89beta-catenin induces precocious lobuloalveolar development and differentiation in the mammary glands of both male and female mice. Virgin DeltaN89beta-catenin mammary glands resemble those found in wild-type (wt) pregnant mice and inappropriately express cyclin D1 mRNA. In contrast to wt mammary glands, which resume a virgin appearance after cessation of lactation, transgenic mammary glands involute to a midpregnant status. All transgenic females develop multiple aggressive adenocarcinomas early in life. Surprisingly, the DeltaN89beta-catenin phenotype differs from those elicited by overexpression of Wnt genes in this gland. In particular, DeltaN89beta-catenin has no effect on ductal side branching. This suggests that Wnt induction of ductal branching involves additional downstream effectors or modulators. |
