|  Help  |  About  |  Contact Us

Publication : C5a is not involved in experimental autoimmune myasthenia gravis pathogenesis.

First Author  Qi H Year  2008
Journal  J Neuroimmunol Volume  196
Issue  1-2 Pages  101-6
PubMed ID  18455242 Mgi Jnum  J:139786
Mgi Id  MGI:3810049 Doi  10.1016/j.jneuroim.2008.03.007
Citation  Qi H, et al. (2008) C5a is not involved in experimental autoimmune myasthenia gravis pathogenesis. J Neuroimmunol 196(1-2):101-6
abstractText  C5 deficient mice are highly resistant to experimental autoimmune myasthenia gravis (EAMG) despite intact immune response to acetylcholine receptor (AChR), validating the pivotal role played by membrane attack complex (MAC, C5b-9) in neuromuscular junction destruction. To distinguish the significance of C5a from that of C5b in EAMG pathogenesis, C5a receptor (C5aR) knockout (KO) and wild-type (WT) mice were immunized with AChR to induce pathogenic anti-AChR antibodies. In contrast with C5 deficient mice, C5aR KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and lymphocyte proliferation response to AChR implicating that C5a is not involved in EAMG development.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

3 Bio Entities

0 Expression