Primary Identifier | MGI:3028651 | Allele Type | Targeted |
Gene | Stat3 | Transmission | Germline |
Strain of Origin | Not Specified | Is Recombinase | false |
Is Wild Type | false |
molecularNote | In order to ablate serine phosphorylation at codon 727, a serine to alanine substitution mutation was introduced into exon 23 at codon 727 via homologous recombination. A floxed neo cassette inserted downstream of the polyadenylation signal was excised via cre-mediated recombination. |