| First Author | Torborg CL | Year | 2005 |
| Journal | Nat Neurosci | Volume | 8 |
| Issue | 1 | Pages | 72-8 |
| PubMed ID | 15608630 | Mgi Jnum | J:95818 |
| Mgi Id | MGI:3527366 | Doi | 10.1038/nn1376 |
| Citation | Torborg CL, et al. (2005) High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections. Nat Neurosci 8(1):72-8 |
| abstractText | Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in several mutant mice with differing levels of eye-specific segregation, we show that the presence of high-frequency bursts synchronized across neighboring retinal ganglion cells correlates with robust eye-specific segregation and that the presence of high levels of asynchronous spikes does not inhibit this segregation. These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in retinogeniculate segregation. |
