Primary Identifier | MGI:3033223 | Allele Type | Chemically induced (ENU) |
Gene | Gck | Inheritance Mode | Dominant |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | T to G transversion in exon 6 results in a missense mutation and substitution of arginine for methionine at amino acid 224. Real time PCR on liver samples detected no change in Gck mRNA expression however liver protein levels and Gck activity are reduced |