|  Help  |  About  |  Contact Us

Allele : Gck<Rgsc392> glucokinase; RIKEN Genomic Sciences Center (GSC), 392

Primary Identifier  MGI:3033225 Allele Type  Chemically induced (ENU)
Gene  Gck Inheritance Mode  Dominant
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false Project Collection  RIKEN GSC ENU Project
molecularNote  G to A transition in exon 5 results in a missense mutation and substitution of methionine for valine at amino acid 182. Real time PCR and immunoblotting found no change in liver Gck mRNA and protein expression however liver Gck activity was reduced. This same mutation is found in human MODY2 patients
  • mutations:
  • Single point mutation
  • synonyms:
  • Gck<4Rgsc>,
  • Gck<V182M>,
  • Gck<V182M>,
  • Rgsc392,
  • Gck<4Rgsc>,
  • M-392,
  • Rgsc392,
  • early onset diabetes, 4 RIKEN GSC,
  • early onset diabetes, 4 RIKEN GSC,
  • M-392
Quick Links:
 
Quick Links:
 

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories