| First Author | Kyuwa S | Year | 2002 |
| Journal | Virus Res | Volume | 83 |
| Issue | 1-2 | Pages | 169-77 |
| PubMed ID | 11864749 | Mgi Jnum | J:91691 |
| Mgi Id | MGI:3050195 | Doi | 10.1016/s0168-1702(01)00432-4 |
| Citation | Kyuwa S, et al. (2002) Acute hepatic failure in IFN-gamma-deficient BALB/c mice after murine coronavirus infection. Virus Res 83(1-2):169-77 |
| abstractText | We previously showed that an intraperitoneal infection with mouse hepatitis virus (MHV) persists in interferon-gamma (IFN-gamma)-deficient C57BL/6 (B6-GKO) mice and results in subacute fatal peritonitis, which bears a resemblance to feline infectious peritonitis. To examine the role of other host factors in MHV infection in mice, IFN-gamma-deficient mice with a BALB/c background (BALB-GKO) were infected intraperitoneally with MHV and compared with B6-GKO mice. In contrast to B6-GKO mice, BALB-GKO mice died within 1 week due to acute hepatic failure. The viral titer of the liver in BALB-GKO mice was significantly higher than that in B6-GKO mice. All hepatocytes in BALB-GKO mice were necrotic at 5 days post-infection, which was clearly distinct from large but limited lesion in the liver from infected B6-GKO mice. The serum alanine aminotransferase activity of infected BALB-GKO mice were higher than that of B6-GKO mice and was paralleled with the severity of the pathological changes and viral titers in infected mice. Administration of exogenous IFN-gamma to BALB-GKO partially inhibited the acute death. These results indicate that BALB-GKO and B6-GKO mice clearly show different diseases following MHV infection, although wild type counterparts of both mice apparently showed the same clinical course after MHV infection. |
