| First Author | Zhang F | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 9 | Pages | 4613-20 |
| PubMed ID | 14568935 | Mgi Jnum | J:86188 |
| Mgi Id | MGI:2678975 | Doi | 10.4049/jimmunol.171.9.4613 |
| Citation | Zhang F, et al. (2003) A murine locus on chromosome 18 controls NKT cell homeostasis and th cell differentiation. J Immunol 171(9):4613-20 |
| abstractText | Th cell differentiation is a critical event in the adaptive immune response. C57BL strains develop predominant Th1 responses while BALB/c develops a predominant Th2 response. To identify quantitative trait loci controlling this variation, we performed Th1/Th2 differentiation assays of F(1) x BALB/c progeny. A single strong quantitative trait locus was identified on chromosome 18, with weaker effects detectable on chromosomes 5, 12, and 14. By preparing a congenic BALB.B10.D2c18 strain, we were able to demonstrate that this single locus was sufficient to 'repolarize' spleen cell cultures. This difference was not due to intrinsic differences in CD4(+) T cells. Rather, introgression of the chromosome 18 locus into BALB/c disrupted Va14Ja18 NKT cell homeostasis resulting in the almost complete absence of this T cell subset. Taken together, these data indicate that genes within chromosome 18 control strain-dependent development of Va14Ja18 NKT cells. |
