| Primary Identifier | MGI:3036686 | Allele Type | Gene trapped |
| Attribute String | Null/knockout, Reporter | Gene | Acly |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | mutant ES cell line = NPX098 (Bay Genomics). Bay Genomics has withdrawn this line from public access, according to their web site. |
| molecularNote | The gene was disrupted by the random integration of the pGT1TMpfs gene trap vector into intron 1. The mutation results in the production of a fusion transcript consisting of sequences from exon 1 of Acly and Beta-geo. In heterozygotes, northern and western blot analyses showed an approximately 50% reduction in mRNA and protein expression. |
