| First Author | Reeves SR | Year | 2004 |
| Journal | Respir Physiol Neurobiol | Volume | 141 |
| Issue | 1 | Pages | 13-20 |
| PubMed ID | 15234672 | Mgi Jnum | J:134597 |
| Mgi Id | MGI:3789395 | Doi | 10.1016/j.resp.2004.03.005 |
| Citation | Reeves SR, et al. (2004) Platelet-activating factor receptor and respiratory and metabolic responses to hypoxia and hypercapnia. Respir Physiol Neurobiol 141(1):13-20 |
| abstractText | Activation of the platelet-activating factor receptor (PAFR) regulates neural transmission. A PAFR blocker reduced the peak hypoxic (pHVR) but not hypercapnic ventilatory (HCVR) responses in rats [Am. J. Physiol. 275 (1998) R604]. To further examine the role of PAFR in respiratory control, genotype-verified PAFR -/- and PAFR +/+ adult male mice underwent hypoxic and hypercapnic challenges. HCVR was similar in the two groups (p-NS). However, pHVR was significantly reduced in PAFR -/- mice (38 +/- 13% baseline [S.D.]) compared to PAFR +/+ mice (78 +/- 16% baseline; P < 0.001, ANOVA), with reduced tidal volume recruitments during pHVR. In addition, hypoxic ventilatory depression was attenuated in PAFR -/- mice (P < 0.01), and was primarily due to attenuation of the time-dependent decreases in oxygen consumption during sustained hypoxia (P < 0.01). Thus, PAFR expression/function modulates components of the acute ventilatory and metabolic adaptations to hypoxia but not to hypercapnia. Imbalances in PAFR activity may lead to maladaptive regulation of the tightly controlled metabolic-ventilatory relationships during hypoxia. |
