| First Author | Megosh LC | Year | 2002 |
| Journal | Genomics | Volume | 79 |
| Issue | 4 | Pages | 505-12 |
| PubMed ID | 11944982 | Mgi Jnum | J:75743 |
| Mgi Id | MGI:2177718 | Doi | 10.1006/geno.2002.6736 |
| Citation | Megosh LC, et al. (2002) Genetic control of polyamine-dependent susceptibility to skin tumorigenesis. Genomics 79(4):505-12 |
| abstractText | Overexpression of an ornithine decarboxylase (ODC) transgene greatly increases the susceptibility of mouse skin to carcinogen-induced tumor development. Like many phenotypes in transgenic models, this enhanced susceptibility phenotype is strongly influenced by genetic background. We have mapped tumor-modifier genes in intraspecific crosses between transgenic K6/ODC mice on a susceptible strain background (C57Bl/6J), a moderately resistant background (FVB), or a highly resistant background (C3H/HeJ). We identified several quantitative trait loci that influenced either tumor multiplicity or predisposition to the development of squamous cell carcinoma, but not both phenotypes. Because we did not use a tumor-promotion protocol to induce tumors, most of the quantitative trait loci mapped in this study are distinct from skin tumor-susceptibility loci identified previously. The use of a combined transgenic-standard strain approach to genetic analysis has resulted in detection of previously unknown genetic loci affecting skin tumor susceptibility. (c)2002 Elsevier Science (USA). |
