| Primary Identifier | MGI:3038611 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Prnp)e19hCwe |
| Is Recombinase | false | Is Wild Type | false |
| description | Two founder lines were generated, E19h and E19l. Both lines were capable of restoring susceptibility to scrabies in Prnp nul mutants |
| molecularNote | To define the requirements of the prion protein for conferring susceptibility to scrapie, deletion mutants of the mouse Prnp gene were constructed and used to generate transgenic mice on a background homozygous for a targeted mutation of the endogenous Prnp gene. In this transgenic line, the sequence encoding two of the five copies of the octa repeat (amino acids 68-83) was deleted, in addition to the larger of the two introns. |
