| Primary Identifier | MGI:3038693 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Il7r |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Homologous recombination was used to replace exon 2, containing a conserved cysteine motif, with a neo cassette. RT-PCR revealed a shorter transcript in homozygous mutants than that of wild-type mice, putatively lacking exon 2 and resulting in a frame shift mutation. Flow cytometry indicated an absence of protein surface expression on homozygous spleen cells. |
