| Help | About | Contact Us

Allele : Pappa<tm1Cac> pregnancy-associated plasma protein A; targeted mutation 1, Cheryl Conover

Primary Identifier	MGI:3037868	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Pappa
Transmission	Germline	Strain of Origin	129
Is Recombinase	false	Is Wild Type	false

molecularNote

A neo cassette replaced 1.6 kb of the gene including most of exon 4. RT-PCR confirmed lack of expression and IGFBP4 proteolysis confirmed lack of Pappa activity in homozygous mutants.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Pappa<->,
Pappa<->,
PAPP-A KO,
PAPP-A KO

earliestPublication:
Conover CA, et al. (2004) Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development 131(5):1187-94

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

25 Publication categories

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=74471890

MouseMine