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Allele : Pappa<tm1Cac> pregnancy-associated plasma protein A; targeted mutation 1, Cheryl Conover

Primary Identifier	MGI:3037868	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Pappa
Transmission	Germline	Strain of Origin	129
Is Recombinase	false	Is Wild Type	false

molecularNote

A neo cassette replaced 1.6 kb of the gene including most of exon 4. RT-PCR confirmed lack of expression and IGFBP4 proteolysis confirmed lack of Pappa activity in homozygous mutants.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
PAPP-A KO,
PAPP-A KO,
Pappa<->,
Pappa<->

earliestPublication:
Conover CA, et al. (2004) Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development 131(5):1187-94

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

25 Publication categories

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