| First Author | Good-Jacobson KL | Year | 2015 |
| Journal | J Exp Med | Volume | 212 |
| Issue | 7 | Pages | 1001-9 |
| PubMed ID | 26077717 | Mgi Jnum | J:226355 |
| Mgi Id | MGI:5697124 | Doi | 10.1084/jem.20150191 |
| Citation | Good-Jacobson KL, et al. (2015) c-Myb is required for plasma cell migration to bone marrow after immunization or infection. J Exp Med 212(7):1001-9 |
| abstractText | Plasma cell migration is crucial to immunity, but little is known about the molecular regulators of their migratory programs. Here, we detail the critical role of the transcription factor c-Myb in determining plasma cell location. In the absence of c-Myb, no IgG(+) antigen-specific plasma cells were detected in the bone marrow after immunization or virus infection. This was correlated with a dramatic reduction of plasma cells in peripheral blood, mislocalization in spleen, and an inability of c-Myb-deficient plasma cells to migrate along a CXCL12 gradient. Therefore, c-Myb plays an essential, novel role in establishing the long-lived plasma cell population in the BM via responsiveness to chemokine migration cues. |
