| First Author | Milano CA | Year | 1994 |
| Journal | Science | Volume | 264 |
| Issue | 5158 | Pages | 582-6 |
| PubMed ID | 8160017 | Mgi Jnum | J:17862 |
| Mgi Id | MGI:65887 | Doi | 10.1126/science.8160017 |
| Citation | Milano CA, et al. (1994) Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor [see comments]. Science 264(5158):582-6 |
| abstractText | Transgenic mice were created with cardiac-specific overexpression of the beta 2-adrenergic receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol. These results illustrate a useful approach for studying the effect of gene expression on cardiac contractility. Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial beta-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state. |
