| Primary Identifier | MGI:3039799 | Allele Type | Chemically induced (ENU) |
| Gene | Itpkb | Inheritance Mode | Recessive |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A T to A transversion at position 596 of the transcript created a premature stop codon in place of cysteine 199. Northern blot revealed abundant transcript in mutant DP thymocytes, putatively encoding an N-terminally truncated protein lacking the targeting, regulating, and catalytic domains. Western blot detected no full-length protein. Kinase activity was about 50% less than that in wild-type thymocytes. |
