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Allele : Trp53<tm3Tyj> transformation related protein 53; targeted mutation 3, Tyler Jacks

Primary Identifier	MGI:3039265	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Trp53
Transmission	Germline	Strain of Origin	129S4/SvJae
Is Recombinase	false	Is Wild Type	false

molecularNote

A targeting construct was designed to insert a loxP site flanked STOP cassette into intron 1 and a p.R270H missense mutation into exon 8.

mutations:
Nucleotide substitutions,
Insertion

cellLines:
Not Specified

synonyms:
p53<LSL-R270H>,
p53 LSL-R270H,
p53<LSL•R270H>,
LSL-p53<R270H>,
p53<LSL•R270H>,
p53 LSL-R270H,
LSL-p53<R270H>,
p53<LSL-R270H>

earliestPublication:
de Vries A, et al. (2002) Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci U S A 99(5):2948-53

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

3 Carried By

0 Driven By

50 Publication categories

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