| First Author | Bosman LW | Year | 2006 |
| Journal | Brain Cell Biol | Volume | 35 |
| Issue | 1 | Pages | 87-101 |
| PubMed ID | 17940915 | Mgi Jnum | J:128737 |
| Mgi Id | MGI:3767923 | Doi | 10.1007/s11068-006-9002-z |
| Citation | Bosman LW, et al. (2006) Requirement of TrkB for synapse elimination in developing cerebellar Purkinje cells. Brain Cell Biol 35(1):87-101 |
| abstractText | The receptor tyrosine kinase TrkB and its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5), are critically important for growth, survival and activity-dependent synaptic strengthening in the central nervous system. These TrkB-mediated actions occur in a highly cell-type specific manner. Here we report that cerebellar Purkinje cells, which are richly endowed with TrkB receptors, develop a normal morphology in trkB-deficient mice. Thus, in contrast to other types of neurons, Purkinje cells do not need TrkB for dendritic growth and spine formation. Instead, we find a moderate delay in the maturation of GABAergic synapses and, more importantly, an abnormal multiple climbing fiber innervation in Purkinje cells in trkB-deficient mice. Thus, our results demonstrate an involvement of TrkB receptors in synapse elimination and reveal a new role for receptor tyrosine kinases in the brain. |
