| First Author | Matza D | Year | 2008 |
| Journal | Immunity | Volume | 28 |
| Issue | 1 | Pages | 64-74 |
| PubMed ID | 18191595 | Mgi Jnum | J:131148 |
| Mgi Id | MGI:3773083 | Doi | 10.1016/j.immuni.2007.11.020 |
| Citation | Matza D, et al. (2008) A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Immunity 28(1):64-74 |
| abstractText | Engagement of the T cell antigen receptor (TCR) during antigen presentation initiates a coordinated action of a large number of signaling proteins and ion channels. AHNAK1 is a scaffold protein, highly expressed by CD4+ T cells, and is a critical component for calcium signaling. We showed that AHNAK1-deficient mice were highly susceptible to Leishmania major infection. AHNAK1-deficient CD4+ T cells responded poorly to TCR stimulation in vitro with low proliferation and low Interleukin-2 production. Furthermore, AHNAK1 deficiency resulted in a reduced calcium influx upon TCR crosslinking and subsequent poor activation of the transcription factor NFAT. AHNAK1 was required for plasma membrane expression of L-type calcium channels alpha 1S (Cav1.1), probably through its interaction with the beta regulatory subunit. Thus, AHNAK1 plays an essential role in T cell Ca2+ signaling through Cav1 channels, triggered via TCR activation; therefore, AHNAK1 is a potential target for therapeutic intervention. |
