Primary Identifier | MGI:3040891 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Zfp148 |
Transmission | Chimeric | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
description | Haploinsufficiency of Zfp148 prevents genetic transmission of the mutated allele and generation of non-chimeric heterozygous mice. All phenotype data reported are from chimeric mice. |
molecularNote | Exon 9, which makes up over 60% of the coding region, was replaced with a neo cassette via homologous recombination. Northern blot analysis showed decreased expression in heterozygous stem cells. |