| First Author | Miyazaki Y | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 373 |
| Issue | 3 | Pages | 397-402 |
| PubMed ID | 18572017 | Mgi Jnum | J:139190 |
| Mgi Id | MGI:3807441 | Doi | 10.1016/j.bbrc.2008.06.038 |
| Citation | Miyazaki Y, et al. (2008) Amelioration of delayed-type hypersensitivity responses by IL-27 administration. Biochem Biophys Res Commun 373(3):397-402 |
| abstractText | Interleukin (IL-) 27 is a member of the IL-12 cytokine family. Although recent analyses of WSX-1 (IL-27 receptor alpha chain)-deficient mice as well as in vitro studies using recombinant IL-27 revealed the immunosuppressive function of IL-27, in vivo role and therapeutic potential of IL-27 remain poorly elucidated. Here we investigated the effect of IL-27 administration on delayed-type hypersensitivity (DTH). While WSX-1-deficient mice showed higher DTH responses as shown by the degree of footpad swelling, administration of IL-27 significantly ameliorated the footpad swelling. Since the activation status of the draining lymph node cells were not affected by IL-27 deficiency, it was suggested that IL-27 affected the effector phase of the response. These results collectively indicate that IL-27 has a suppressive effect on activated T cells in the experimental model and also has a therapeutic potential for some diseases caused by immune disorder. |
