| First Author | Artis D | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 8 | Pages | 4672-5 |
| PubMed ID | 15067040 | Mgi Jnum | J:89112 |
| Mgi Id | MGI:3038525 | Doi | 10.4049/jimmunol.172.8.4672 |
| Citation | Artis D, et al. (2004) Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection. J Immunol 172(8):4672-5 |
| abstractText | There are conflicting reports on the requirements for the IL-27-WSX-1 pathway in the development of Th type 1 responses and resistance to intracellular pathogens; although early IFN-gamma production and resistance to Leishmania major are impaired in the absence of WSX-1 signaling, WSX-1(-/-) mice generate robust IFN-gamma responses and control infection with other intracellular protozoan pathogens. In this report, we resolve these conflicting observations and demonstrate that, in the absence of IL-4, WSX-1 is not required for early IFN-gamma production and control of L. major. Thus, the requirement for WSX-1 signaling in Th type 1 cell differentiation is restricted to conditions in which IL-4 is produced. |
