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Allele : Wfs1<tm1Yoka> wolframin ER transmembrane glycoprotein; targeted mutation 1, Yoshitomo Oka

Primary Identifier	MGI:3044175	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Wfs1
Transmission	Germline	Strain of Origin	129/Sv
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin-resistance gene was inserted into the second exon, which contains the initial ATG codon. Western blot indicated absence of protein in mutant brains.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
wfs1-,
wfs1-

earliestPublication:
Ishihara H, et al. (2004) Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. Hum Mol Genet 13(11):1159-70

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

12 Publication categories

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