Primary Identifier | MGI:3044558 | Allele Type | Chemically induced (ENU) |
Gene | Gck | Inheritance Mode | Dominant |
Strain of Origin | BALB/c | Is Recombinase | false |
Is Wild Type | false |
molecularNote | An A to T transversion is found at position 1096 in exon 9. This results in a missense amino acid change from isoleucine to phenylalanine at position 366. Western blot analysis did not find any significant change in protein expression although glucose phosphorylating activity was significantly impaired. This mutation was generated as part of the Harwell/SB ENU mutagenesis project. |