| First Author | Wallace DF | Year | 2004 |
| Journal | Genesis | Volume | 39 |
| Issue | 1 | Pages | 38-41 |
| PubMed ID | 15124225 | Mgi Jnum | J:89758 |
| Mgi Id | MGI:3041368 | Doi | 10.1002/gene.20023 |
| Citation | Wallace DF, et al. (2004) Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: loxP system. Genesis 39(1):38-41 |
| abstractText | Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in TfR2 lead to type 3 hemochromatosis in humans. We have developed mice with a targeted deletion of TfR2. The Cre-recombinase:loxP system used to create the mice allows both full deletion and tissue-specific deletion of TfR2. The development of these mice will provide new models for type 3 hemochromatosis and assist in determining the role of TfR2 in iron metabolism. |
