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Allele : Drd3<tm1Stl> dopamine receptor D3; targeted mutation 1, Susumu Tonegawa

Primary Identifier	MGI:3044114	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Drd3
Transmission	Germline	Strain of Origin	129S2/SvPas
Is Recombinase	false	Is Wild Type	false

molecularNote

A PGK-neo cassette replaced exon 1. Southern blot analysis confirmed recombination. Autoradiographic analysis confirmed the absence of Drd3 binding sites in brains of homozygous mice.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
D3R KO,
D3R<->,
D3<->,
D3R<->,
D3R KO,
D3<->

earliestPublication:
Xu M, et al. (1997) Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron 19(4):837-48

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

33 Publication categories

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