| First Author | Kisielow P | Year | 1988 |
| Journal | Nature | Volume | 335 |
| Issue | 6192 | Pages | 730-3 |
| PubMed ID | 3262831 | Mgi Jnum | J:79737 |
| Mgi Id | MGI:2388862 | Doi | 10.1038/335730a0 |
| Citation | Kisielow P, et al. (1988) Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335(6192):730-3 |
| abstractText | Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II molecules encoded by the major histocompatibility complex (MHC) by virtue of the heterodimeric alpha beta T-cell receptor (TCR). CD4 and CD8 molecules expressed on the surface of T cells bind to nonpolymorphic portions of class II and class I MHC molecules and assist the TCR in binding and possibly in signalling. The analysis of T-cell development in TCR transgenic mice has shown that the CD4/CD8 phenotype of T cells is determined by the interaction of the alpha beta TCR expressed on immature CD4+8+ thymocytes with polymorphic domains of thymic MHC molecules in the absence of nominal antigen. Here we provide direct evidence that positive selection of antigen-specific, class I MHC-restricted CD4-8+ T cells in the thymus requires the specific interaction of the alpha beta TCR with the restricting class I MHC molecule. |
