| Primary Identifier | MGI:3043425 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Camk2a-MME)3Selk |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| description | Homozygous mutant mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Transgenic mice have poor reproductive performance. In conjunction with Tg(PDGFB-APPSwInd)20Lms, transgenic mice do not develop amyloid beta plaques. |
| molecularNote | Transgenic mice express human membrane metallo-endopeptidase (MME) under the direction of the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) promoter. Transgene expression is approximately 8 fold relative to wildtype controls, as detected by quantitative Western blot analysis and protease activity assay. The levels of soluble alpha beta-amyloid X-40 and soluble alpha beta-amyloid X-42 are reduced in 2 to 3 month old transgenic mice. |
