| First Author | Capel B | Year | 1993 |
| Journal | Nat Genet | Volume | 5 |
| Issue | 3 | Pages | 301-7 |
| PubMed ID | 8275095 | Mgi Jnum | J:15425 |
| Mgi Id | MGI:63547 | Doi | 10.1038/ng1193-301 |
| Citation | Capel B, et al. (1993) Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. Nat Genet 5(3):301-7 |
| abstractText | An approach designed to map and generate mutations in the region of the short arm of the mouse Y chromosome, known to be involved in sex determination and spermatogenesis, is described. This relies on homologous Yp-Sxra pairing and asymmetrical exchange which can occur at meiosis in XY males carrying Sxra on their X chromosome. Such exchange potentially generates deficiencies and duplications of Yp or Sxra. Three fertile XY females were found out of about 450 XY offspring from XSxra/Y x XX crosses. In all three, despite evidence for deletion of Y chromosomal material, the Sry locus was intact. Each deletion involved a repeat sequence, Sx1, located at a distance from Sry. Since expression of Sry was affected these results suggest that long range position effects have disrupted Sry action. |
