| Primary Identifier | MGI:3043986 | Allele Type | Targeted |
| Gene | Ppp3r1 | Transmission | Germline |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Sequence encoding an FRB* peptide tag was inserted into exon 5, immediately following the last codon of the coding sequence. This allele produces a protein with a C-terminal FRB* peptide tag that prevents interaction with PPP3CA, thereby eliminating calcium-dependent activation of PPP3CA catalytic activity. An assay indicated the abrogation of caclcineurin phosphatase activity. |
